Accepted Preprint (first posted online 12 January 2016)

    N-terminal POMC peptides and adrenal growth

    1. Andrew B. Bicknell
    1. A Bicknell, School of Biological Sciences, The University of Reading, Reading, United Kingdom of Great Britain and Northern Ireland
    1. Correspondence: Andrew B. Bicknell, Email: a.b.bicknell{at}


    The peptide hormones contained within the sequence of Proopiomelanocortin (POMC) have diverse roles from pigmentation, regulation of adrenal function to control of our appetite. It is generally acknowledged to be the archetypal hormone precursor and as its biology has been unravelled, so too have many of the basic principles of hormone biosynthesis and processing. This short review focuses on one group of its peptide products, namely those derived from the N-terminal of POMC and their role in the regulation of adrenal growth. From a historical and personal perspective, it describes how their role in regulating proliferation of the adrenal cortex was identified and also highlights the key questions that remain to be answered.

    • Received 3 November 2015
    • Revision received 6 January 2016
    • Accepted 12 January 2016
    • Accepted Preprint first posted online on 12 January 2016

    This Article

    1. J Mol Endocrinol JME-15-0269
    1. Abstract
    2. All Versions of this Article:
      1. JME-15-0269v1
      2. 56/4/T39 most recent

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