Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

    1. Jihong Kang
    1. Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
      1Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China
    1. Correspondence should be addressed to J Kang; Email: kangjihong{at}


    Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

    • Revision received 15 January 2013
    • Accepted 18 January 2013
    • Made available online as an Accepted Preprint 18 January 2013
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