The orphan nuclear receptors at their 25-year reunion

  1. Mitchell A Lazar
  1. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
  1. Correspondence should be addressed to M A Lazar; Email: lazar{at}
  1. Figure 1

    Orphan NR Timeline. From the late 1980s till the end of the 1990s, there was rapid growth of the NR superfamily with the addition of 36 orphan members. Once the cloning and discovery of novel members plateaued, the focus of the field shifted to intense functional characterization. Here each orphan is listed by its common name and color-coded based on its designated NR subfamily.

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