The regulation and function of the NUAK family

  1. Jiajun Zhao1
  1. 1Department of Endocrinology
    2Central Laboratory, Provincial Hospital affiliated to Shandong University, Jinan, China
    3Department of Endocrinology and Metabolism, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan
    4Department of Dentistry, School of Dentistry, Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan
    5Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
  1. Correspondence should be addressed to W-C Li or J Zhao; Email: wcli{at} or jjzhao{at}
  1. Figure 1

    Functional interplay of ARKs. LKB1 often phosphorylates ARKs at threonine 172 (T172) of AMPK and corresponding sites of other ARKs (shown as black bars). After phosphorylation/activation, the AMPK-associated kinases could share common physiological regulation of cell polarity or cell motility by controlling assembly/disassembly of cytoskeletal proteins. Full color version of this figure available via

  2. Figure 2

    Cellular and molecular regulatory circuits for (A) NUAK1 and (B) NUAK2. All abbreviations are described in text. Full colour version of this figure available via

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