Role of leptin in the pancreatic β-cell: effects and signaling pathways

    1. Ivan Quesada1,2
    1. 1Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Elche, Spain
      2Instituto de Bioingeniería, Universidad Miguel Hernández de Elche, Avenida de la Universidad, s/n, 03202 Elche, Spain
    1. (Correspondence should be addressed to I Quesada at Instituto de Bioingeniería, Universidad Miguel Hernández de Elche; Email: ivanq{at}


    Leptin plays an important role in the control of food intake, energy expenditure, metabolism, and body weight. This hormone also has a key function in the regulation of glucose homeostasis. Although leptin acts through central and peripheral mechanisms to modulate glucose metabolism, the pancreatic β-cell of the endocrine pancreas is a critical target of leptin actions. Leptin receptors are present in the β-cell, and their activation directly inhibits insulin secretion from these endocrine cells. The effects of leptin on insulin occur also in the long term, since this hormone inhibits insulin gene expression as well. Additionally, β-cell mass can be affected by leptin through changes in proliferation, apoptosis, or cell size. All these different functions in the β-cell are triggered by leptin as a result of the large diversity of signaling pathways that this hormone is able to activate in the endocrine pancreas. Therefore, leptin can participate in glucose homeostasis owing to different levels of modulation of the pancreatic β-cell population. Furthermore, it has been proposed that alterations in this level of regulation could contribute to the impairment of β-cell function in obesity states. In the present review, we will discuss all these issues with special emphasis on the effects and pathways of leptin signaling in the pancreatic β-cell.

    • Revision received 22 March 2012
    • Accepted 23 March 2012
    • Made available online as an Accepted Preprint 23 March 2012
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