Somatostatin system: molecular mechanisms regulating anterior pituitary hormones

    1. Anat Ben-Shlomo
    1. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Pituitary Center, Cedars Sinai Medical Center, Davis Building, Room 3066, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    1. Correspondence should be addressed to A Ben-Shlomo; Email: benshlomoa{at}


    The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1–5) activates multiple cellular signaling pathways including adenylate cyclase/cAMP, MAPK, ion channel-dependent pathways, and others. In addition, recent data have suggested SRIF-independent constitutive SRIF receptor activity responsible for GH and ACTH inhibition in vitro. This review summarizes current knowledge on ligand-dependent and independent SRIF receptor molecular and functional effects on hormone-secreting cells in the anterior pituitary gland.

    • Revision received 17 April 2014
    • Accepted 24 April 2014
    • Made available online as an Accepted Preprint 29 April 2014
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