Searching journal content for diabetes (as phrase) in full text.

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  1. ...diabetes contributes to a vast 85–90% of the diabetes incidences while 10–15% of patients suffer from type 1 diabetes. These two predominant forms of DM cause a significant loss of functional pancreatic β-cell mass causing different degrees of insulin deficiency, most likely, due to increased β-cell ~~~
  2. ...diabetes mellitus (T2DM), obesity, hypertension, hyperlipidemia, etc. Growing Journal of Molecular Endocrinology (2017) 59, 121–128 Correspondence should be addressed to H Chen or W Jia Email [email protected] or [email protected] Key Words f 5-aminolevulinic acid f nonalcoholic fatty liver diseas ~~~
  3. ...diabetes ~~~
  4. ...diabetes ~~~
  5. ...diabetes in Lepr(db/db) mice. J Biol Chem 282 15717-15729. 560 Shukla U, Tumma N, Gratsch T, Dombkowski A & Novak RF 2013 Insights into insulin-mediated 561 regulation of CYP2E1: miR-132/-212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase, 562 Akt (protein kinase B), mammalian target ~~~
  6. ...diabetes in humans (Guan et al. 2010, Majumdar & Weber 2012, Gonzalez et al. 2015). However, unlike NMBR/GRPR, human or mouse BRS3 cannot be effectively activated by GRP/NMB (EC50 >>1000 nM), or by any other naturally occurring bombesin-related peptides (Mantey et al. 1997, Ryan et al. 1998). Hence, ~~~
  7. ...diabetes mellitus (Guh et al. 2009). Multiple factors can contribute to the development of obesity, among which is the transgenerational effects of maternal obesity. It has been shown in animal models and humans that offspring born to obese mothers tend to have higher risk of obesity and related com ~~~
  8. ...diabetes (T2D) and cardiovascular disease (CVD) including hyperlipidaemia, hypertension, inflammation, oxidative stress, procoagulation, impaired fibrinolysis and early vascular markers of atherosclerosis including endothelial dysfunction, arterial stiffness, increased carotid intima media wall thic ~~~
  9. ...diabetes 27 mellitus (T2DM) 28 Word count: 5513 29 30 Page 2 of 59 3 Abstract 31 Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with complicated 32 pathogenesis, and targeting gluconeogenesis inhibition is a promising strategy for 33 anti-diabetic drug discovery. G protein-coupled re ~~~
  10. ...diabetes and obesity (Berger & Moller 2002, Feige et al. 2006). In vertebrates, three PPARs have been identified which are encoded by three different genes: PPARα, PPARβ (also called PPARδ) and PPARγ. They regulate gene expression by binding to PPAR response elements (PPREs) as a heterodimer with RX ~~~
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