Accepted Preprint (first posted online 30 August 2013)

    Interactions between endocrine and circadian systems

    1. Henrik Oster
    1. A Tsang, Medical Department I, University of Lübeck, Lübeck, Germany
    2. J Barclay, Genes & Behavior, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
    3. H Oster, Medical Department I, University of Lübeck, Lübeck, Germany
    1. Correspondence: Henrik Oster, Email: Henrik.Oster{at}


    In most species endogenous circadian clocks regulate 24-hour rhythms of behaviour and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review we describe the mechanisms of clock-hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed-back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

    • Received 21 June 2013
    • Revision received 22 August 2013
    • Accepted 29 August 2013
    • Accepted Preprint first posted online on 30 August 2013

    This Article

    1. J Mol Endocrinol JME-13-0118
    1. Abstract
    2. All Versions of this Article:
      1. JME-13-0118v1
      2. 52/1/R1 most recent