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The image depicts the regulatory sequences of the rat POMC gene. In addition to the promoter, three enhancer sequences contribute to either pituitary or hypothalamic expression of POMC. The diagrams depict current knowledge on DNA binding transcription factors acting on these enhancers. From Drouin 2016 56 T99–T112. Credit: J Drouin, Institut de recherches cliniques de Montréal (IRCM), Montréal, Canada