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Figure 6

Coactivator binding to the surface of the LBD. (A) Shown is the RORβ LBD structure with an agonist ligand (blue) that places helix-12 (H12) in the active conformation. From this position, H12 fosters the interactions of an LXXLL motif contained in most p160 coactivators with the surface of the LBD. The LXXLL motif forms a small helical segment, allowing the leucines along one face to firmly dig into a hydrophobic groove on the surface of the LBD. The X residues in the coactivator motif are typically polar and interact with the solvent. Notice that the ligand (blue) is shielded from solvent when H12 is in the active conformation.

This Article

  1. J Mol Endocrinol vol. 51 no. 3 T1-T21