About the Cover

The image depicts three related structures: a comparison of coactivator and corepressor binding in PPARα, (left) active on agonist binding, (centre) corepressor binding after helix-12 deplacement by an antagonist, and (right) direct corepressor binding. The full figure is presented on page T10 of this issue. Credit: Fraydoon Rastinejad, Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida, USA.