Transcriptional coregulator RIP140: an essential regulator of physiology

    1. Jaya Nautiyal
    1. Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, UK
    1. Correspondence should be addressed to J Nautiyal; Email: j.nautiyal{at}


    Transcriptional coregulators drive gene regulatory decisions in the transcriptional space. Although transcription factors including all nuclear receptors provide a docking platform for coregulators to bind, these proteins bring enzymatic capabilities to the gene regulatory sites. RIP140 is a transcriptional coregulator essential for several physiological processes, and aberrations in its function may lead to diseased states. Unlike several other coregulators that are known either for their coactivating or corepressing roles, in gene regulation, RIP140 is capable of acting both as a coactivator and a corepressor. The role of RIP140 in female reproductive axis and recent findings of its role in carcinogenesis and adipose biology have been summarised.

    • Received 26 December 2016
    • Accepted 10 January 2017
    • Made available online as an Accepted Preprint 10 January 2017
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