Acromegaly is associated with increased cancer risk: a survey in Italy

  1. for the Italian Study Group of Acromegaly*
  1. 1Internal Medicine 1, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy
  2. 2Statistical Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Italy
  3. 3Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
  4. 4Pituitary Unit, Department of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy
  5. 5Division of Endocrinology, Department of Clinical Medicine and Surgery, University Federico II di Napoli, Naples, Italy
  6. 6Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, ASOU Città della Salute e della Scienza, Turin, Italy
  7. 7Pituitary Unit, Department of Neurosurgery, San Raffaele Scientific Institute, University ‘Vita- Salute’, Milan, Italy
  8. 8Department of Clinical and Experimental Medicine-Endocrinology Unit, University of Messina, Messina, Italy
  9. 9Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DiMI), Center of Excellence for Biomedical Research (CEBR) IRCCS, AOU San Martino-IST, San Martino Hospital, University of Genova, Genova, Italy
  10. 10Ambulatori di Endocrinologia, Humanitas Gavazzeni, Bergamo, Italy
  11. 11Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy
  12. 12Internal Medicine, San Valentino Hospital, Montebelluna, Treviso, Italy
  13. 13Internal Medicine, Department of Medicine, DIMED, University of Padova, Padova, Italy
  14. 14Department of Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
  15. 15Department of Internal Medicine, Section of Endocrinology and Metabolism, University of Modena, Modena, Italy
  16. 16Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences ‘Mario Serio’, University of Florence, Florence, Italy
  17. 17IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy
  18. 18Endocrinology, AO Garibaldi-Nesima, Catania, Italy
  19. 19Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
  20. 20Division of Endocrinology and Metabolism, Santa Croce and Carle Hospital, Cuneo, Italy
  21. 21Endocrinology Unit, Department of Medicine, DIMED University of Padua, Padua, Italy
  22. 22Endocrinology, Sant’Antonio Abate Hospital, Gallarate, Varese, Italy
  23. 23Endocrinology Unit A.O. San Camillo - Forlanini, Rome, Italy
  24. 24Division of Endocrine and Metabolic Diseases, San Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy
  1. Correspondence should be addressed to G Reimondo; Email: giuseppe.reimondo{at}
  1. Figure 1

    Sample size of the population-based studies on acromegaly and cancer. Black bars indicate studies showing a positive association between acromegaly and cancer, striped bars indicate negative studies, and white bars indicate studies that do not conclude whether an association is either present or not. Studies which focus on mortality only are marked by the letter M. 1, Mustacchi & Shimkin (1957); 2, Wright et al. (1970); 3, Alexander et al. (1980); 4, Bengtsson et al. (1988); 5, Nabarro (1987); 6, Pines et al. (1985); 7, Barzilay et al. (1991); 8, Ron et al. (1991); 9, Rajasoorya et al. (1994); 10, Cheung & Boyages (1997); 11, Orme et al. (1998); 12, Popovic et al. (1998); 13, Higuchi et al. (2000); 14, Baris et al. (2002); 15, Holdaway et al. (2004); 16, Ayuk et al. (2004); 17, Kurimoto et al. (2008); 18, Gullu et al. (2010); 19, Bałdys-Waligórska et al. (2010); 20, Kauppinen-Mäkelin et al. (2010); 21, Arosio et al. (2012); 22, Dagdelen et al. (2014); 23, Mercado et al. (2014); 24, Petroff et al. (2015); 25, Cheng et al. (2015); 26, Dal et al. (2016); 27, Maione et al. (2017).

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