Animal models of medullary thyroid cancer: state of the art and view to the future

  1. on behalf of NIKE Group
  1. 1Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
  2. 2Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano IRCCS, Milan, Italy
  3. 3Department of Experimental Oncology, Laboratory of Molecular Biology and Viral Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, ‘Fondazione Pascale’ – IRCCS, Naples, Italy
  4. 4Department of Endocrinology and Internal Medicine, Endocrine Tumors Unit, San Raffaele Hospital Vita-Salute San Raffaele University, Milan, Italy
  5. 5Department of Physics, Politecnico di Milano, Milan, Italy
  6. 6Department of Biosciences, University of Milan, Milan, Italy
  7. 7Thyroid and Parathyroid Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione G. Pascale’ – IRCCS, Naples, Italy
  8. 8Department of Clinical Medicine and Surgery, Section of Endocrinology, ‘Federico II’ University of Naples, Naples, Italy
  1. Correspondence should be addressed to G Vitale; Email: giovanni.vitale{at}
  1. Figure 1

    MTC-grafted cells stimulate angiogenesis in zebrafish embryos. Representative confocal microscopic images of Tg(fli1:EGFP)y1 zebrafish embryos implanted with red fluorescence-stained MZ-CRC1 (B and D) cells. 24 (A and B) and 48 (C and D) hours after injection (hpi), larvae were embedded in low-melting agarose, and the yolk region was observed by confocal microscopy. In comparison to control larvae (A and B), MTC-grafted larvae showed endothelial structures (green) that sprout from the subintestinal vein (SIV) plexus and the common cardinal vein (CCV) (B and D) and progressively form new vessels. All images are oriented so that rostral is to the left and dorsal is at the top. Scale bar, 50 μm.

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