Genomic actions of estrogen receptor α: what are the targets and how are they regulated?

    1. Hendrik G Stunnenberg
    1. Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, PO Box 9101, HB Nijmegen, The Netherlands Departments of
      1Chemical Endocrinology
      2Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    1. (Correspondence should be addressed to H G Stunnenberg; Email: h.stunnenberg{at}


    The estrogen receptor α (ERα) is a ligand-dependent transcription factor that regulates a large number of genes in many different target tissues and is important in the development and progression of breast cancer. ERα-mediated transcription is a complex process regulated at many different levels. The interplay between ligand, receptor, DNA sequence, cofactors, chromatin context, and post-translational modifications culminates in transcriptional regulation by ERα. Recent technological advances have allowed the identification of ERα target genes on a genome-wide scale. In this review, we provide an overview of the progress made in our understanding of the different levels of regulation mediated by ERα. We discuss the recent advances in the identification of the ERα-binding sites and target gene network and their clinical applications.

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