20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders

  1. Christos Mantzoros1,2
  1. Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, Illinois 60637, USA
    1Division of Endocrinology, Diabetes, and Metabolism, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, FD-876, Boston, Massachusetts 02215, USA
    2Section of Endocrinology, Boston VA Healthcare System, Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence should be addressed to C Mantzoros; Email: cmantzor{at}bidmc.harvard.edu
  1. Figure 1

    Schematic illustration of the interactions of leptin with the hypothalamic–pituitary–gonadal axis. Leptin stimulates POMC/CART and Glut neurons and inhibits AgRP/NPY and GABA neurons to modulate reproduction centrally. At the ovaries, leptin can have different effects depending on the metabolic status. AgRP, agouti-related peptide; CART, cocaine and amphetamine-regulated transcript; FSH, follicle-stimulating hormone; GABA, gamma-aminobutyric acid; Glut, glutamate; GnRH, gonadotropin-releasing hormone; LH, luteinizing hormone; NKB, neurokinin B; NPY, neuropeptide Y; PMV, ventral premammillary nucleus; POMC, proopiomelanocortin.

| Table of Contents