The role of adipose tissue immune cells in obesity and low-grade inflammation

    1. Martin Haluzik
    1. Third Department of Medicine – Department of Endocrinology and Metabolism, General University Hospital, First Faculty of Medicine of Charles University in Prague, U nemocnice 1, 128 00 Prague 2, Czech Republic
    1. Correspondence should be addressed to M Mraz; Email: milos_mraz{at}


    Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.

    • Received in final form 3 July 2014
    • Accepted 8 July 2014
    • Made available online as an Accepted Preprint 8 July 2014
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