Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

    1. Crispin R Dass2,3
    1. College of Health and Biomedicine, Victoria University, St Albans, Victoria 3021, Australia
      1School of Biomedical Sciences
      2Biosciences Research Precinct
      3School of Pharmacy, Curtin University, Bentley, Perth, Western Australia 6102, Australia
    1. Correspondence should be addressed to C R Dass; Email: Crispin.Dass{at}


    Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

    • Received in final form 5 June 2014
    • Accepted 11 June 2014
    • Made available online as an Accepted Preprint 13 June 2014
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