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Thematic Review:
- Jong-Ik Hwang,
- Seongsik Yun,
- Mi Jin Moon,
- Cho Rong Park,
- and Jae Young Seong
MOLECULAR EVOLUTION OF GPCRS: GLP1/GLP1 receptors J Mol Endocrinol 52 (3) T15-T27, doi: 10.1530/JME-13-0137 first published on 5 March 2014
...Cark Kor diabetes mellitus and obesity. Studies using synteny and reconstructed ancestral chromosomes suggest that families for GLP1 and its receptor (GLP1R) have emerged through " GLP1 " gene " duplication pancreatic b-cells and promotes insulin synthesis (Schmidt et al. 1985, Fehmann & Habener...
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Research:
- Ying Ying,
- Huazhang Zhu,
- Zhen Liang,
- Xiaosong Ma,
- and Shiwei Li
GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway J Mol Endocrinol 55 (3) 245-262, doi: 10.1530/JME-15-0155 first published on 18 September 2015
...GLP1 protects cardiomyocytes from Akt/GSK3b/b-catenin pathway Correspondence should be addressed to Y Ying Email [email protected] decreased phosphorylation of protein kinase B (Akt) and glycogen synthase kinase-3b (GSK3b) in palmitate-stimulated cardiomyocytes. In contrast, inhibition of Akt...
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Research:
- Srividya Vasu,
- R Charlotte Moffett,
- Neville H McClenaghan,
- and Peter R Flatt
Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells J Mol Endocrinol 54 (1) 91-104, doi: 10.1530/JME-14-0214 first published on 19 December 2014
..., but a-TC1 cells were less severely affected. Thus, responses of GLP1-secreting L-cells to cytotoxicity resemble b-cells, whereas a-cells are resistant due to differences in the expression of genes involved in cytotoxicity or antioxidant defence. Journal of Molecular Endocrinology (2015) 54, 91–104"i...
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Research:
- Yingyu Feng,
- Lei Su,
- Xing Zhong,
- Wei Guohong,
- Haipeng Xiao,
- Yanbing Li,
- and Lingling Xiu
Exendin-4 promotes proliferation and differentiation of MC3T3-E1 osteoblasts by MAPKs activation J Mol Endocrinol 56 (3) 189-199, doi: 10.1530/JME-15-0264 first published on 8 December 2015
...’s Republic of China Research Role of exendin-4 in MC3T3-E1 cells 10.1530/JME-15-0264 y feng and others 56 :3 56:3 Journal of Molecular Endocrinology (2016) 56, 189–199 189–199 Correspondence should be addressed to L Xiu Email [email protected] Key Words f GLP1 f exendin-4 f osteoblast f MC3T3-E1 cells f...
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Research:
- Rune Ehrenreich Kuhre,
- Nicolai Jacob Wewer Albrechtsen,
- Carolyn Fiona Deacon,
- Emilie Balk-Møller,
- Jens Frederik Rehfeld,
- Frank Reimann,
- Fiona Mary Gribble,
- and Jens Juul Holst
Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells J Mol Endocrinol 56 (3) 201-211, doi: 10.1530/JME-15-0293 first published on 27 January 2016
...the intestine. The gut hormone, glucagon-like peptide-1 (GLP-1), is a key hormone in the regulation of blood glucose and satiety in humans. It is produced by enteroendocrine L-cells located in the gut epithelium, and is particularly known for its incretin actions , that is, the enhancement Correspondence should...
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Review:
- Ahmed A Hasan and
- Berthold Hocher
Role of soluble and membrane-bound dipeptidyl peptidase-4 in diabetic nephropathy J Mol Endocrinol 59 (1) R1-R10, doi: 10.1530/JME-17-0005 first published on 18 April 2017
...that these reno-protective effects could be due to increased half-life of DPP-4 substrates such as glucagon-like peptide-1 (GLP-1) and stromal derived factor-1 alpha (SDF-1a). However, the underlying mechanisms are far from being completely understood and clearly need further investigations. Introduction...
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Research:
- Jin-Seung Choung,
- Young-Sun Lee,
- and Hee-Sook Jun
Exendin-4 increases oxygen consumption and thermogenic gene expression in muscle cells J Mol Endocrinol 58 (2) 79-90, doi: 10.1530/JME-16-0078 first published on 21 November 2016
...Gachon Medical Research Institute, Gil Hospital, Incheon, Republic of Korea *(J-S Choung and Y-S Lee contributed equally to this work) Abstract Glucagon-like peptide-1 (GLP1) has many anti-diabetic actions and also increases energy expenditure in vivo. As skeletal muscle is a major organ controlling...
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Research:
- Jianling Xie,
- Norhan M El Sayed,
- Cheng Qi,
- Xuechan Zhao,
- Claire E Moore,
- and Terence P Herbert
Exendin-4 stimulates islet cell replication via the IGF1 receptor activation of mTORC1/S6K1 J Mol Endocrinol 53 (1) 105-115, doi: 10.1530/JME-13-0200
...University Road, Leicester LE1 9HN, UK *(J Xie and N M El Sayed contributed equally to this work) Email increase b-cell mass. Key Words " mTORC1 " PKB/AKT " b-cell " IGF1R " GLP1 Journal of Molecular characterized by high blood glucose in the context of development of T2DM. However, although...
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Research:
- Xun Cao,
- Xiao Zhou,
- Xiao-Min Liu,
- and Li-Hong Zhou
Liraglutide alters DPP4 in the circumvallate papillae of type 2 diabetic rats J Mol Endocrinol 57 (1) 13-21, doi: 10.1530/JME-16-0001 first published on 5 May 2016
...Endocrinology (2016) 57, 13–21 13–21 Key Words f DPP4 f taste f T2DM f liraglutide Correspondence should be addressed to Xiao-Min Liu or Li-Hong Zhou Email [email protected] or [email protected] Abstract Liraglutide, a human glucagon-like peptide (GLP1) analog that partially inhibits dipeptidyl-peptidase 4...
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Research:
- Özlem Erdogdu,
- Linnéa Eriksson,
- Hua Xu,
- Åke Sjöholm,
- Qimin Zhang,
- and Thomas Nyström
Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways J Mol Endocrinol 50 (2) 229-241, doi: 10.1530/JME-12-0166 first published on 23 January 2013
...tO¨zlem Erdogdu*, Linne´a Eriksson*, Hua Xu1, Åke Sjo¨holm, Qimin Zhang to T Nystro¨m Email thomas.nystrom@ sodersjukhuset.se with exendin-4 and GLP1 (7–36) protected HCAECs against lipoapoptosis, an effect that was blocked by PKA, PI3K/Akt, eNOS, p38 MAPK, and JNK inhibitors. Genetic silencing...

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