Searching journal content for articles similar to Hanson et al. 52 (3): 333.

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  1. Regular papers:
    • Christian Fottner,
    • Timo Minnemann,
    • Sarah Kalmbach,
    • and Matthias M Weber
    Overexpression of the insulin-like growth factor I receptor in human pheochromocytomas J Mol Endocrinol 36 (2) 279-287, doi: 10.1677/jme.1.01975
    ...-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E et al. 1986 Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specifity. EMBO Journal 5 2503–2512. Wang L, Wei D & Huang S 2003...
  2. Articles:
    • L Badinga,
    • S Song,
    • RC Simmen,
    • JB Clarke,
    • DR Clemmons,
    • and FA Simmen
    Complex mediation of uterine endometrial epithelial cell growth by insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 J Mol Endocrinol 23 (3) 277-285, doi: 10.1677/jme.0.0230277
    [email protected].) (S Song is now at Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida 32610, USA) ABSTRACT The coexpression of IGF (-I and -II) peptides, corresponding receptors, and IGF binding proteins (IGFBPs) in uterine endometrium suggests that a significant component...
  3. Review:
    • Zodwa Dlamini,
    • Fortunate Mokoena,
    • and Rodney Hull
    Abnormalities in alternative splicing in diabetes: therapeutic targets J Mol Endocrinol 59 (2) R93-R107, doi: 10.1530/JME-17-0049
    ...the balance of pro-apoptotic caspase family and anti-apoptotic Bcl proteins toward apoptosis, leading to β-cell death (Tomita 2016, 2017). In type 2 diabetes this may be controlled through the insulin receptor. The insulin receptor (INSR) has two isoforms, the shorter INSR-A, which is the result of skipping...
  4. Review:
    • Annu Makker,
    • Madhu Mati Goel,
    • and Abbas Ali Mahdi
    PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update J Mol Endocrinol 53 (3) R103-R118, doi: 10.1530/JME-14-0220 first published on 13 October 2014
    ...). Hunzicker-Dunn et al. (2012) identified a pathway by which FSH-stimulated PKA appropriates growth factor receptor-bound protein 2-associated binding protein 2 (GAB2) and insulin receptor substrate 1 adapters to activate the PI3K pathway in GCs. Reports are available on the synergistic actions of IGF1...
  5. Review:
    • Zhen-Yu She and
    • Wan-Xi Yang
    Molecular mechanisms involved in mammalian primary sex determination J Mol Endocrinol 53 (1) R21-R37, doi: 10.1530/JME-14-0018 first published on 13 June 2014
    ...to activate its expression. A p38 MAP3K4 signaling cascade, including GADD45g-p38 MAPK-GATA4SRY, is involved in the regulation of normal SRY expression during sex determination. The insulin receptor tyrosine kinase family, comprising Ir, Irr, Igf1r, and Cbx2, is responsible for the normal Sry expression...
  6. Regular papers:
    • Dellel Rezgui,
    • Christopher Williams,
    • Sharon A Savage,
    • Stuart N Prince,
    • Oliver J Zaccheo,
    • E Yvonne Jones,
    • Matthew P Crump,
    • and A Bassim Hassan
    Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth J Mol Endocrinol 42 (4) 341-356, doi: 10.1677/JME-08-0154 first published on 10 February 2009
    ...(Linnell et al. 2001, Williams et al. 2007, Brown et al. 2008). IGF2 is a small hydrophobic ligand (7.5 kDa) utilises the same binding site on IGF2 that is recognised 341Journal of Molecular Endocrinology (2009) 42, 341–356transforming growth factor b1 (latent-TGFb1), where activation of the latter...
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  7. Review:
    • Gabriele Capurso,
    • Stefano Festa,
    • Roberto Valente,
    • Matteo Piciucchi,
    • Francesco Panzuto,
    • Robert T Jensen,
    • and Gianfranco Delle Fave
    Molecular pathology and genetics of pancreatic endocrine tumours J Mol Endocrinol 49 (1) R37-R50, doi: 10.1530/JME-12-0069 first published on 14 May 2012
    ...of growth factors and their receptors offers the opportunity for targeted therapy. The surface of PET cells presents several growth factor receptors, including receptor tyrosine kinases such as epidermal growth factor receptor (EGFR), insulin-like growth factor 1 receptor (IGF1R), hepatocite growth factor...
  8. Review:
    • Thomas Svava Nielsen,
    • Niels Jessen,
    • Jens Otto L Jørgensen,
    • Niels Møller,
    • and Sten Lund
    Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease J Mol Endocrinol 52 (3) R199-R222, doi: 10.1530/JME-13-0277 first published on 27 February 2014
    ...by interfering with insulin signaling at the level of the insulin receptor substrate (IRS) proteins (Boura-Halfon & Zick 2009, Copps & White 2012). Being the major lipid species released from AT, FFA is likely one of the key elements in ectopic lipid accumulation and lipotoxicity. Thus, experimental elevation...
  9. Articles:
    • SA Akker,
    • PJ Smith,
    • and SL Chew
    Nuclear post-transcriptional control of gene expression J Mol Endocrinol 27 (2) 123-131, doi: 10.1677/jme.0.0270123
    .... Furthermore, variation in posttranscriptional processing provides substantial mRNA and protein diversity, with multiple isoforms generated from single genes. For example, the single human insulin-like growth factor-I (IGF-I) gene has three alternatively spliced isoforms (Jansen et al. 1983, Rotwein 1986, Chew...
  10. Regular papers:
    • H Wang,
    • Y Horikawa,
    • L Jin,
    • T Narita,
    • S Yamada,
    • N Shihara,
    • K Tatemoto,
    • M Muramatsu,
    • T Mune,
    • and J Takeda
    Gene expression profile in rat pancreatic islet and RINm5F cells J Mol Endocrinol 35 (1) 1-12, doi: 10.1677/jme.1.01738
    ...of the insulin/insulin-like growth factor (IGF) family have been implicated both in the regulation of pancreatic -cell growth and insulin secretion. IRR, an orphan receptor of the insulin receptor subfamily, is expressed at a considerably higher level in pancreatic cells (Hirayama et al. 1999), and a decrease...
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