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Figure 8

Comparison of coactivator and corepressor binding modes. (A) The synthetic ligand GW731 is an agonist of PPARα, producing the active conformation and allowing for favorable coactivator binding. (B) In contrast, the synthetic molecule GW6471 displaces helix-12 in this receptor and helps create a stable conformation that allows for a region of the corepressor SMRT to bind onto the surface. (C) The binding of the Rev-Erbα LBD to a corepressor element in the absence of ligand.

This Article

  1. J Mol Endocrinol vol. 51 no. 3 T1-T21