The many ways to make a luminal cell and a prostate cancer cell

    1. Andrew S Goldstein1
    1. Department of Urology, University of Texas Southwestern, Dallas, Texas, USA
      1Department of Molecular and Medical Pharmacology, Department of Urology, David Geffen School of Medicine, Broad Stem Cell Research Center, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA
    1. Correspondence should be addressed to A S Goldstein; Email: AGoldstein{at}


    Research in the area of stem/progenitor cells has led to the identification of multiple stem-like cell populations implicated in prostate homeostasis and cancer initiation. Given that there are multiple cells that can regenerate prostatic tissue and give rise to prostate cancer, our focus should shift to defining the signaling mechanisms that drive differentiation and progenitor self-renewal. In this article, we will review the literature, present the evidence and raise important unanswered questions that will help guide the field forward in dissecting critical mechanisms regulating stem-cell differentiation and tumor initiation.

    • Revision received 21 August 2015
    • Accepted 24 August 2015
    • Made available online as an Accepted Preprint 25 August 2015
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