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Figure 1

A possible diagnostic work-up in palpable thyroid nodules.1Control visit after 4 weeks (clinical examination plus ultrasound; FNAB – if indicated by, for example, palpable solid remnants of the cyst or peripherally localized solid tissue within the cystic lesion). 2Next visit after 6–8 weeks and then a 3 month interval (supplementary l-T4 therapy if indicated; surgery if relapse). 3Higher risk of malignancy in nonclassic subtype. 4Consider molecular markers: if positive–surgery, if negative–surgery in cold and hot nodules vs follow-up in a warm nodule. 5Next visit after 4–6 weeks and then a 3 month interval (l-T4 – if indicated and consider FNAB or direct surgery if tumor enlargement or suspicious appearance on US). 6Any palpable solid/or mixed, cold/or hot nodule should be removed even with benign cytology but the time and the extent of surgery may differ, depending on all the diagnostic data.

This Article

  1. Endocr Relat Cancer vol. 13 no. 2 427-453