Searching journal content for splice variant (as phrase) in full text.

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  1. Thematic Review:
    • Melissa Gamat and
    • Douglas G McNeel
    Androgen deprivation and immunotherapy for the treatment of prostate cancer Endocr Relat Cancer 24 (12) T297-T310, doi:10.1530/ERC-17-0145 first published on 16 August 2017
    ...splice variant androgen receptors. Neoplasia 14 74–IN12. Yu Z, Cai C, Gao S, Simon NI, Shen HC & Balk SP 2014 Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor. Clinical Cancer Research 20 4075–4085. (doi:10.1158/1078-0432.CCR-14-0292) Re ~~~
  2. Review:
    • Takuma Uo,
    • Stephen R Plymate,
    • and Cynthia C Sprenger
    Allosteric alterations in the androgen receptor and activity in prostate cancer Endocr Relat Cancer 24 (9) R335-R348, doi:10.1530/ERC-17-0108
    ...splice variant expression patterns. European Urology 72 192–200. (doi:10.1016/j.eururo.2017.01.011) Dehm SM 2013a mRNA splicing variants: exploiting modularity to outwit cancer therapy. Cancer Research 73 5309–5314. (doi:10.1158/0008-5472.CAN-13-0444) Dehm SM 2013b Test-firing ammunition for spliceo ~~~
  3. Thematic Review:
    • Roberta Visconti and
    • Domenico Grieco
    Fighting tubulin-targeting anticancer drug toxicity and resistance Endocr Relat Cancer 24 (9) T107-T117, doi:10.1530/ERC-17-0120
    ...regression. However, most prostate cancers develop resistance to it. As illustrated in Fig.1, acquired resistance is mostly the result of AR gene amplification or of point mutations and expression of splice variants coding for more sensitive, less specific or constitutively active AR proteins (Wadosky ~~~
  4. Review:
    • Sangeeta Kumari,
    • Dhirodatta Senapati,
    • and Hannelore V Heemers
    Rationale for the development of alternative forms of androgen deprivation therapy Endocr Relat Cancer 24 (8) R275-R295, doi:10.1530/ERC-17-0121 first published on 31 May 2017
    ...splice variant expression patterns. European Urology pii S0302-2838(17)30018-0. (doi:10.1016/ j.eururo.2017.01.011) Dehm SM, Schmidt LJ, Heemers HV, Vessella RL & Tindall DJ 2008 Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate can ~~~
  5. Research:
    • Eleanor L Woodward,
    • Andrea Biloglav,
    • Naveen Ravi,
    • Minjun Yang,
    • Lars Ekblad,
    • Johan Wennerberg,
    • and Kajsa Paulsson
    Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines Endocr Relat Cancer 24 (5) 209-220, doi:10.1530/ERC-16-0522 first published on 24 February 2017
    ...its effects since the structure of the NEGR1 protein has not been determined. There are three normal splice variants of NEGR1: NEGR1_001, including exons 1a7; transcript NEGR1_002, including exons 1b7; and NEGR1_201, including exons 1a3 and 57. RNA-Seq did not show any overall difference ~~~
  6. Review:
    • Jennifer Munkley
    Glycosylation is a global target for androgen control in prostate cancer cells Endocr Relat Cancer 24 (3) R49-R64, doi:10.1530/ERC-16-0569 first published on 3 February 2017
    ...androgens ( Sharma et al . 2013 , Mills 2014 ). AR signalling can be maintained through gene amplification ( Visakorpi et al . 1995 ), activating mutations ( Veldscholte et al . 1990 , Steinkamp et al . 2009 ), AR splice variants ( Sun et al . 2010 , Cao et al . 2016 ) or crosstalk with other oncogenic ~~~
  7. Thematic Review:
    • Isabel Coutinho,
    • Tanya K Day,
    • Wayne D Tilley,
    • and Luke A Selth
    Androgen receptor signaling in castration-resistant prostate cancer: a lesson in persistence Endocr Relat Cancer 23 (12) T179-T197, doi:10.1530/ERC-16-0422 first published on 31 October 2016
    ...a profound impact on our knowledge of aberrant AR signaling. AR splice variants The addiction of prostate cancer cells to AR, manifested by extreme pressure to maintain AR expression and activity, is also associated with the emergence of truncated forms of the receptor. Many of these AR variants (AR-Vs) lack ~~~
  8. Thematic Review:
    • Subing Cao,
    • Yang Zhan,
    • and Yan Dong
    Emerging data on androgen receptor splice variants in prostate cancer Endocr Relat Cancer 23 (12) T199-T210, doi:10.1530/ERC-16-0298 first published on 4 October 2016
    ..., Louisiana, USA Abstract Androgen receptor splice variants are alternatively spliced variants of androgen receptor, which are C-terminally truncated and lack the canonical ligand-binding domain. Accumulating evidence has indicated a significant role of androgen receptor splice variants in mediating ~~~
  9. Thematic Review:
    • Muhammed H Rahaman,
    • Malika Kumarasiri,
    • Laychiluh B Mekonnen,
    • Mingfeng Yu,
    • Sarah Diab,
    • Hugo Albrecht,
    • Robert W Milne,
    • and Shudong Wang
    Targeting CDK9: a promising therapeutic opportunity in prostate cancer Endocr Relat Cancer 23 (12) T211-T226, doi:10.1530/ERC-16-0299 first published on 31 August 2016
    ...; exon 4 for hinge; and exons 5, 6, 7 and 8 for LBD. All the AR splice variants share similarity with the NTD and DBD. Introduction of cryptic exons due to exon skipping or alternative splicing results in unique regions. T215Thematic Review M H Rahaman, MKumarasiri etal. Targeting CDK9 in prostate ~~~
  10. Thematic Review:
    • Thomas J Sweet and
    • Angela H Ting
    WOMEN IN CANCER THEMATIC REVIEW: Diverse functions of DNA methylation: implications for prostate cancer and beyond Endocr Relat Cancer 23 (11) T169-T178, doi:10.1530/ERC-16-0306 first published on 7 September 2016
    .... urology.2003.08.039) GuoZ, YangX, SunF, JiangR, LinnDE, ChenH, ChenH, KongX, MelamedJ, TepperCG, etal. 2009 A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Research 69 23052313. (doi:10 ~~~
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