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Editorial:
- Joanne Y Y Ngeow and
- Laura S Ward
Cancer immunotherapy: unique perspectives for endocrine-related cancers Endocr Relat Cancer 24 (12) E13-E14, doi:10.1530/ERC-17-0413
...neuroendocrine cancers and adrenocortical cancers. It is evident from their review that across the different tumor subtypes, there is tremendous variability in efficacy in using checkpoint inhibitors. This is in part because we are as yet unable to predict and define the tumor-specific (and context- ~~~
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Thematic Review:
- Lucas Leite Cunha,
- Marjory Alana Marcello,
- Vinicius Rocha-Santos,
- and Laura Sterian Ward
Immunotherapy against endocrine malignancies: immune checkpoint inhibitors lead the way Endocr Relat Cancer 24 (12) T261-T281, doi:10.1530/ERC-17-0222 first published on 11 September 2017
...neuroendocrine tumors. We present the challenges and the opportunities of using immune checkpoint inhibitors against these endocrine malignancies, highlighting the breakthroughs and pitfalls that have recently emerged. Introduction Immune checkpoint inhibitors are agents that act by inhibiting immun ~~~
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Thematic Review:
- Robert C Mould,
- Jacob P van Vloten,
- Amanda W K AuYeung,
- Khalil Karimi,
- and Byram W Bridle
Immune responses in the thyroid cancer microenvironment: making immunotherapy a possible mission Endocr Relat Cancer 24 (12) T311-T329, doi:10.1530/ERC-17-0316 first published on 14 September 2017
...neuroendocrine cancer. Clinical Cancer Research 14 4298–4305. (doi:10.1158/1078-0432.CCR-08-0587) Pardoll DM 2012 The blockade of immune checkpoints in cancer immunotherapy. Nature Reviews Cancer 12 252–264. (doi:10.1038/ nrc3239) Parhar RS, Zou M, Al-Mohanna FA, Baitei EY, Assiri AM, Meyer BF & Shi ~~~
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Thematic Review:
- Stephan Gasser,
- Lina H K Lim,
- and Florence S G Cheung
The role of the tumour microenvironment in immunotherapy Endocr Relat Cancer 24 (12) T283-T295, doi:10.1530/ERC-17-0146 first published on 28 July 2017
...neuroendocrine NCT02628067 Prembrolizumab II; not yet recruiting Anti-PD1 Thyroid, neuroendocrine NCT03012620 Prembrolizumab I; recruiting Anti-PD1 Thyroid, pancreatic Enoblituzumab (MGA271) NCT02475213 Prembrolizumab II; not yet recruiting Anti-PD1 Thyroid Lenvatinib NCT02973997 Prembrolizumab II; ~~~
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Review:
- Joanna Grey and
- Kym Winter
Patient quality of life and prognosis in MEN2 Endocr Relat Cancer ERC-17-0335, doi:10.1530/ERC-17-0335 first published on 24 October 2017
...neuroendocrine 7 tumour syndromes, MEN type 2A (MEN2A) and MEN type 2B (MEN2B). They are typified by the 8 development of medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid 9 hyperplasia in MEN2A, and MTC, phaeochromocytomas, ganglioneuromatosis and skeletal 10 abnormalities in MEN ~~~
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Review:
- Vincenzo Marotta,
- Maria Chiara Zatelli,
- Concetta Sciammarella,
- Maria Rosaria Ambrosio,
- Marta Bondanelli,
- Annamaria A L Colao,
- and Antongiulio Faggiano
Chromogranin A as circulating marker for diagnosis and management of neuroendocrine neoplasms: more flaws than fame Endocr Relat Cancer ERC-17-0269, doi:10.1530/ERC-17-0269 first published on 24 October 2017
...neuroendocrine 1 neoplasms: more flaws than fame 2 3 Vincenzo Marotta , Maria Chiara Zatelli , Concetta Sciammarella , Maria Rosaria Ambrosio , 4 Marta Bondanelli , Annamaria Colao , Antongiulio Faggiano 5 1. Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy 6 2. Sec ~~~
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Research:
- Zhu Wang,
- Dinglan Wu,
- Chi-Fai Ng,
- Jeremy Yuen-Chun Teoh,
- Shan Yu,
- Yuliang Wang,
- and Franky Leung Chan
Nuclear receptor profiling in prostatospheroids and castration-resistant prostate cancer Endocr Relat Cancer ERC-17-0280, doi:10.1530/ERC-17-0280 first published on 17 October 2017
...neuroendocrine cell-specific phenotype and loss of AR, of which treatment option is limited 73 and results in high mortality. Accumulating evidences suggest that prostate cancer 74 stem/progenitor-like cells (PCSCs; also called prostate cancer stem cells, tumor initiating or 75 progenitor cells) may ~~~
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Research:
- Trisha Dwight,
- Aidan Flynn,
- Kaushalya Amarasinghe,
- Diana E Benn,
- Richard Lupat,
- Jason Li,
- Daniel Cameron,
- Annette Hogg,
- Shiva Balachander,
- Ida Lm Candiloro,
- Stephen Wong,
- Bruce G Robinson,
- Anthony T Papenfuss,
- Anthony J Gill,
- Alexander Dobrovic,
- Rodney J Hicks,
- Roderick Clifton-Bligh,
- and Richard William Tothill
TERT structural rearrangements in metastatic pheochromocytomas Endocr Relat Cancer ERC-17-0306, doi:10.1530/ERC-17-0306 first published on 3 October 2017
...neuroendocrine tumors derived from 46 neural-crest cells of the sympathetic and parasympathetic nervous system - PCs arising in the adrenal 47 medulla and PGLs in paraganglia outside the adrenal medulla. Although rare, they often occur as part 48 of hereditary endocrine tumor syndromes and their stu ~~~
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Review:
- Maria Domenica Castellone and
- Rosa Marina Melillo
RET-mediated modulation of tumour microenvironment and immune response in MEN2 Endocr Relat Cancer ERC-17-0303, doi:10.1530/ERC-17-0303 first published on 20 September 2017
...neuroendocrine neoplasia originating 41 from the C cell component of the thyroid gland. MTC accounts for about 5% of all 42 thyroid malignant tumors and can occur either as sporadic (about 75% of cases) or 43 familial (about 25% of cases) form. Hereditary MTC occurs in the context of different 44 au ~~~
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Editorial:
- Frank Weber and
- Lois M Mulligan
Happy 20th anniversary MEN1: from positional cloning to gene function restoration Endocr Relat Cancer 24 (10) E7-E11, doi:10.1530/ERC-17-0346
...neuroendocrine neoplasms, breast and soft tissue tumors) beyond the parathyroid adenoma, gastrinoma and prolactinoma described originally, and also to understand the genetic, epigenetic and post-translational mechanisms behind this disorder. 20th anniversary of the MEN1 gene cloning Researchers arou ~~~

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