Searching journal content for MENX (as phrase) in full text.

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  1. ...the pancreatic neuroendocrine tumors (pNET). For this reason, after identifying these mutations, a new endocrine tumor syndrome was referred to as MENX or, more recently, MEN4 (Thakker 2014). In a recent nationwide study, major differences in the clinical course were found between 30 mutationnegative MEN1 ~~~
  2. .... Mouse models of MEN1 closely resemble the human disease in terms of tumor spectrum and associated hormonal changes, although individual tumor frequencies are variable. Rats affected by the MENX (MEN1-like) syndrome share some features with MEN1 patients albeit they bear a germline mutation in Cdkn1b (p ~~~
  3. ...and pituitary adenomas. Approximately 10% of patients with familial or sporadic MEN1-like phenotype do not have MEN1 mutations or deletions. A novel MEN syndrome was discovered, initially in rats (MENX), and later in humans (MEN4), which is caused by germline mutations in the putative tumor suppressor CDKN1B ~~~
  4. ...MENX ~~~
  5. ...-dependent kinase inhibitor (CDKI) gene CDKN1B/p27 in a rat strain with combined MEN1 and MEN2 features (MENX) prompted the germline mutation analysis of this gene in human patients with MEN1-like features, and the identification of the MEN4 disorder (Pellegataetal. 2006). Heterozygous germline mutations in p27 ~~~
  6. ...-10% patients without menin mutations. A subgroup 454 of these patients (roughly 2%) present with CDKN1B (p27) mutations. Identification 455 of p27 mutations were based on a naturally occurring MEN1 rat model (MENX) 456 presenting with an 8 bp homozygous frameshift insertion leading to a premature stop 457 ~~~
  7. ...the need to identify the effective therapeutic approaches for PCC, we evaluated the antitumor potential of the dual-PI3K/mTOR inhibitor BEZ235 against these tumors. We employed an in vivo model of endogenous PCCs (MENX mutant rats), which closely recapitulate the human tumors. Mutant rats with PCCs were ~~~
  8. ...occurring within the first year of life in a SpragueDawley rat colony (Fritz et al. 2002). This syndrome, termed MENX, consisted of bilateral phaeo, paraganglioma, parathyroid hyperplasia and pituitary adenomas preceded by juvenile cataracts. Despite the clear overlap in clinical features with both MEN1 ~~~
  9. ...MENX ~~~
  10. ...Pathology 36 242252. (doi:10.1097/PAS.0b013e31823d07f3) Lee M, Marinoni I, Irmler M, Psaras T, Honegger JB, Beschorner R, Anastasov N, Beckers J, Theodoropoulou M, Roncaroli F et al. 2013 Transcriptome analysis of MENX-associated rat pituitary adenomas identifies novel molecular mechanisms involved ~~~
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