Searching journal content for Fanconi anemia (as phrase) in full text.

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  1. ...& Bartek 2009, Dexheimer 2013). In general, germline alterations in any of these pathways predispose to an elevated risk of cancer. Many human cancer predisposition syndromes such as Fanconi anemia, ataxia-telangiectasia, Nijmegen breakage syndrome, Bloom syndrome and HNPCC are associated with inherited ~~~
  2. ...Abstract Hereditary breast and ovarian cancer (HBOC) syndrome and a rare childhood disorder Fanconi anemia (FA) are caused by homologous recombination (HR) defects, and some of the causative genes overlap. Recent studies in this field have led to the exciting development of PARP inhibitors as novel cancer ~~~
  3. ...Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Research 63 2688–2694. Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, et al. 2013 Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Disco ~~~
  4. ...the emergence of several human pathologies including cancer. The breast cancer susceptibility gene 2 (BRCA2, also known as the Fanconi anemia (FA) complementation group D1 (FANCD1)) is a potent tumor suppressor that has been extensively studied in DNA double-stranded break (DSB) repair by homologous ~~~
  5. ...M & PetersenG 2005 Germ line Fanconi anemia complementation group C mutations and pancreatic cancer. Cancer Research 65 383386. CouchFJ, JohnsonMR, RabeKG, BruneK, de AndradeM, GogginsM, RothenmundH, GallingerS, KleinA, PetersenGM, etal. 2007 The prevalence of BRCA2 mutations in familial ~~~
  6. the reminder that BRCA2 links DSB to inter-strand crosslink repair, a central function of the Fanconi Anemia family of proteins. Indeed, one of the most striking developments in BRCA2-related research was the discovery by Alan DAndreas group that biallelic mutations in BRCA2 lead to a subtype of Fanconi ~~~
  7. ...genetic predisposition (Kitamura etal. 2014). The likelihood of an intrinsic molecular genomic basis is further supported by the increased incidence of myeloid neoplasia in Fanconi anemia, LiFraumeni syndrome, neurofibromatosis type 1, Down syndrome, as well as in circumstances characterized by genetic ~~~
  8. ...genes, including ATM, ATR, BARD1, BRIP1, MRE11A, PALB2, RAD50, RAD51D, RAD54, NBS1, CHEK1, and CHEK2, as well as components of the Fanconi anemia repair pathway (Hughes-Davies et al. 2003, Taniguchi etal. 2003, Venkitaraman 2003, Dedes et al. 2011, Loveday etal. 2011, Rigakos & Razis 2012, Strom ~~~
  9. ...substrates, known as monoubiquitination, has also been shown to have critical cellular functions. An example of this is monoubiquitination of the Fanconi Anemia protein FANCD2 in response to DNA damage that promotes homologous recombination repair of DNA double strand breaks (Nakanishi et al. 2005 ~~~
  10. ...) and Barreau et al. (2013) hosphatase and tensin homolog; TIMP3, TIMP metallopeptidase inhibitor; st cancer 1; FHIT, fragile histidine triad protein; FANCF, Fanconi anemia gene thyltransferase; CDH1, E-cadherin gene; SPARC, secreted protein, acidic, in gene 2. Published by Bioscientifica Ltd. a relationship ~~~
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