-
Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice
R. Charlotte Moffett, Srividya Vasu, and Peter R. Flatt
Biochimica et Biophysica Acta (BBA) - General Subjects
(2015)
1850 :1206
-
Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell
function and survival
Dawood Khan, Srividya Vasu, R. Charlotte Moffett, Nigel Irwin, and Peter R. Flatt
Molecular and Cellular Endocrinology
(2016)
436 :102
-
A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
P. Marchetti, R. Lupi, M. Bugliani, C. L. Kirkpatrick, G. Sebastiani, F. A. Grieco, S. Del Guerra, V. D’Aleo, S. Piro, L.
Marselli, U. Boggi, F. Filipponi, L. Tinti, L. Salvini, C. B. Wollheim, F. Purrello, and F. Dotta
Diabetologia
(2012)
55 :3262
-
Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells
Young-Sun Lee and Hee-Sook Jun
Metabolism
(2014)
63 :9
-
Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in
Mice
Wenjuan Liu, Dong Ok Son, Harry K. Lau, Yinghui Zhou, Gerald J. Prud’homme, Tianru Jin, and Qinghua Wang
Frontiers in Pharmacology
(2017)
8 :
-
GLP-1-related proteins attenuate the effects of mitochondrial membrane damage in pancreatic β cells
Makiko Ogata, Naoko Iwasaki, Risa Ide, Miho Takizawa, and Yasuko Uchigata
Biochemical and Biophysical Research Communications
(2014)
447 :133
-
Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis
Divya P. Kumar, Amon Asgharpour, Faridoddin Mirshahi, So Hyun Park, Sichen Liu, Yumi Imai, Jerry L. Nadler, John R. Grider,
Karnam S. Murthy, and Arun J. Sanyal
Journal of Biological Chemistry
(2016)
291 :6626
-
Functionality and antidiabetic utility of β- and L-cell containing pseudoislets
Alastair D. Green, Srividya Vasu, and Peter R. Flatt
Experimental Cell Research
(2016)
344 :201
-
GLP-1-Based Strategies: A Physiological Analysis of Differential Mode of Action
Rémy Burcelin, Pierre Gourdy, and Stéphane Dalle
Physiology
(2014)
29 :108
-
Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis
Leonid E. Fridlyand, Louis H. Philipson, and Tao Cai
PLOS ONE
(2016)
11 :e0152869
-
GLP-1 Effects on Islets: Hormonal, Neuronal, or Paracrine?
M. Y. Donath and R. Burcelin
Diabetes Care
(2013)
36 :S145
-
Insights on glicentin, a promising peptide of the proglucagon family
Juliette Raffort, Fabien Lareyre, Damien Massalou, Patrick Fénichel, Patricia Panaïa-Ferrari, and Giulia Chinetti
Biochemia Medica
(2017)
27 :308
-
Elevated glucagon-like peptide-1 plasma levels, as a possible adaptive response, in diabetic NOD mice
T Rydgren, A. Börjesson, A. Carlsson, and S. Sandler
Biochemical and Biophysical Research Communications
(2012)
423 :583
-
Do we know the true mechanism of action of the DPP-4 inhibitors?
Emilie S. Andersen, Carolyn F. Deacon, and Jens J. Holst
Diabetes, Obesity and Metabolism
(2018)
20 :34
-
Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity
Giuseppina Opinto, Annalisa Natalicchio, and Piero Marchetti
Archives of Physiology and Biochemistry
(2013)
119 :170
-
desHis1Glu9-glucagon-[mPEG] and desHis1Glu9(Lys30PAL)-glucagon: Long-acting peptide-based PEGylated and acylated glucagon
receptor antagonists with potential antidiabetic activity
Nigel Irwin, Zara J. Franklin, and Finbarr P.M. O'Harte
European Journal of Pharmacology
(2013)
709 :43
-
Peptide Biosynthesis: Prohormone Convertases 1/3 and 2
Akina Hoshino and Iris Lindberg
Colloquium Series on Neuropeptides
(2012)
1 :1
-
Metabolic regulation of GLP-1 and PC1/3 in pancreatic α-cell line
Veronica Sancho, Giuseppe Daniele, Daniela Lucchesi, Roberto Lupi, Annamaria Ciccarone, Giuseppe Penno, Cristina Bianchi,
Angela Dardano, Roberto Miccoli, Stefano Del Prato, and Nigel Irwin
PLOS ONE
(2017)
12 :e0187836
-
The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms
Mohamed Lotfy, Jaipaul Singh, Hameed Rashed, Saeed Tariq, Erika Zilahi, and Ernest Adeghate
Cell and Tissue Research
(2014)
358 :343
-
Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes
J. M. Castellano, A. Guinda, T. Delgado, M. Rada, and J. A. Cayuela
Diabetes
(2013)
62 :1791
-
The sorting of proglucagon to secretory granules is mediated by carboxypeptidase E and intrinsic sorting signals
R. McGirr, L. Guizzetti, and S. Dhanvantari
Journal of Endocrinology
(2013)
217 :229
-
Progressive change of intra-islet GLP-1 production during diabetes development
Thomas J. O'Malley, Genevieve E. Fava, Yanqing Zhang, Vivian A. Fonseca, and Hongju Wu
Diabetes/Metabolism Research and Reviews
(2014)
30 :661
-
Differential expression of glucagon-like peptide-2 (GLP-2) is involved in pancreatic islet cell adaptations to stress and
beta-cell survival
Dawood Khan, Srividya Vasu, R. Charlotte Moffett, Nigel Irwin, and Peter R. Flatt
Peptides
(2017)
95 :68
-
The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic
mice
Yoji Hamada, Hiroshi Nagasaki, Masahiro Fuchigami, Shinji Furuta, Yusuke Seino, Jiro Nakamura, and Yutaka Oiso
Metabolism
(2013)
62 :734
-
Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy
R. Charlotte Moffett, Srividya Vasu, Bernard Thorens, Daniel J. Drucker, Peter R. Flatt, and Christian Holscher
PLoS ONE
(2014)
9 :e96863
-
On-target Effects of GLP-1 Receptor Agonists on Thyroid C-cells in Rats and Mice
Thomas J. Rosol
Toxicologic Pathology
(2013)
41 :303
-
Alpha cells come of age
Joel F. Habener and Violeta Stanojevic
Trends in Endocrinology & Metabolism
(2013)
24 :153
-
CREB/CRTC2 controls GLP-1–dependent regulation of glucose homeostasis
Ji-Hyun Lee, Xianlan Wen, Hana Cho, and Seung-Hoi Koo
The FASEB Journal
(2018)
32 :1566
-
Tissue expression of DPP-IV in obesity-diabetes and modulatory effects on peptide regulation of insulin secretion
Aine M. McKillop, Claire L. Stevenson, Brian M. Moran, Yasser H.A. Abdel-Wahab, and Peter R. Flatt
Peptides
(2018)
100 :165
-
α-cell role in β-cell generation and regeneration
Joel F. Habener and Violeta Stanojevic
Islets
(2012)
4 :188
-
The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice
Adam P. Chambers, Joyce E. Sorrell, April Haller, Karen Roelofs, Chelsea R. Hutch, Ki-Suk Kim, Ruth Gutierrez-Aguilar, Bailing
Li, Daniel J. Drucker, David A. D’Alessio, Randy J. Seeley, and Darleen A. Sandoval
Cell Metabolism
(2017)
25 :927
-
COMPARISON OF THE LEVELS OF C-REACTIVE PROTEIN, GLP-1 AND GLP-2 AMONG INDIVIDUALS WITH DIABETES, MORBID OBESITY AND HEALTHY
CONTROLS: AN EXPLORATORY STUDY
Everton CAZZO, José Carlos PAREJA, Elinton Adami CHAIM, Cláudio Saddy Rodrigues COY, and Daniéla Oliveira MAGRO
Arquivos de Gastroenterologia
(2018)
55 :72
-
Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct
Effect of GLP-1 on Pancreatic Alpha Cells
Salvatore Piro, Loriana G. Mascali, Francesca Urbano, Agnese Filippello, Roberta Malaguarnera, Salvatore Calanna, Agata M.
Rabuazzo, Francesco Purrello, and Francesco Giorgino
PLoS ONE
(2014)
9 :e90093
-
Oleanolic Acid Improves Gut Atrophy Induced by Parenteral Nutrition
Ajay Kumar Jain, Joy X. Wen, Keith S. Blomenkamp, Sumit Arora, Timothy A. Blaufuss, Jonathan Rodrigues, John P. Long, Brent
A. Neuschwander-Tetri, and Jeffery H. Teckman
Journal of Parenteral and Enteral Nutrition
(2016)
40 :67
-
Naturally-occurring TGR5 agonists modulating glucagon-like peptide-1 biosynthesis and secretion
Laila Jafri, Samreen Saleem, Danielle Calderwood, Anna Gillespie, Bushra Mirza, and Brian D. Green
Peptides
(2016)
78 :51
-
GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets
of Langerhans
Virginia M. Stone, Shalinee Dhayal, Katy J. Brocklehurst, Carol Lenaghan, Maria Sörhede Winzell, Mårten Hammar, Xiufeng Xu,
David M. Smith, and Noel G. Morgan
Diabetologia
(2014)
57 :1182
-
Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress
Srividya Vasu, R. Charlotte Moffett, Bernard Thorens, Peter R. Flatt, and Nigel Irwin
PLoS ONE
(2014)
9 :e101005
-
The multifaceted role of natriuretic peptides in metabolic syndrome
Prasanna K. Santhekadur, Divya P. Kumar, Mulugeta Seneshaw, Faridoddin Mirshahi, and Arun J. Sanyal
Biomedicine & Pharmacotherapy
(2017)
92 :826
-
Candidate Genes Expressed in Human Islets and Their Role in the Pathogenesis of Type 1 Diabetes
Joachim Storling and Caroline Anna Brorsson
Current Diabetes Reports
(2013)
13 :633
-
A 4-week study assessing the pharmacokinetics, pharmacodynamics, safety, and tolerability of the glucagon receptor antagonist
PF-06291874 administered as monotherapy in subjects with type 2 diabetes mellitus
Arthur Bergman, Beesan Tan, Veena R. Somayaji, Roberto A. Calle, and David J. Kazierad
Diabetes Research and Clinical Practice
(2017)
126 :95
-
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
Darleen A. Sandoval and David A. D'Alessio
Physiological Reviews
(2015)
95 :513
-
Intra-islet glucagon-like peptide 1
Genevieve E. Fava, Emily W. Dong, and Hongju Wu
Journal of Diabetes and its Complications
(2016)
30 :1651
-
Pancreatic β-Cell Proliferation in Obesity
Amelia K. Linnemann, Mieke Baan, and Dawn Belt Davis
Advances in Nutrition
(2014)
5 :278
-
Modified Western blotting for insulin and other diabetes-associated peptide hormones
Naoyuki Okita, Yoshikazu Higami, Fumio Fukai, Masaki Kobayashi, Miku Mitarai, Takao Sekiya, and Takashi Sasaki
Scientific Reports
(2017)
7 :
-
Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats
Sarah W. Lai, Elaine de Heuvel, Laurie E. Wallace, Bolette Hartmann, Jens J. Holst, Mary E. Brindle, Prasanth K. Chelikani,
David L. Sigalet, and Xuan-Zheng Shi
PLOS ONE
(2017)
12 :e0181453
-
Glucagon receptor as a drug target: A witches' brew of eye of newt (peptides) and toe of frog (receptors)
Derek J. Nunez and David D'Alessio
Diabetes, Obesity and Metabolism
(2018)
20 :233
-
Decreased serum glicentin concentration in patients with severe and morbid obesity
Juliette Raffort, Patricia Panaïa-Ferrari, Fabien Lareyre, Mathilde Blois, Pascale Bayer, Pascal Staccini, Patrick Fénichel,
and Giulia Chinetti
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
(2018)
55 :198
-
Peptidomic Profiling of Secreted Products from Pancreatic Islet Culture Results in a Higher Yield of Full-length Peptide Hormones
than Found using Cell Lysis Procedures
Steven W. Taylor, Svetlana E. Nikoulina, Nancy L. Andon, and Carolyn Lowe
Journal of Proteome Research
(2013)
12 :3610
-
Dipeptidyl peptidase inhibitor therapy in type 2 diabetes: Control of the incretin axis and regulation of postprandial glucose
and lipid metabolism
Erin E. Mulvihill
Peptides
(2018)
100 :158
-
Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and
24-Week Phase 2 Studies
Christof M. Kazda, Ying Ding, Ronan P. Kelly, Parag Garhyan, Chunxue Shi, Chay Ngee Lim, Haoda Fu, David E. Watson, Andrew
J. Lewin, William H. Landschulz, Mark A. Deeg, David E. Moller, and Thomas A. Hardy
Diabetes Care
(2016)
39 :1241
-
Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders
Nader H. Moniri
Biochemical Pharmacology
(2016)
110-111 :1
-
Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research
Ang Li, Yue Li, and Lupei Du
Future Medicinal Chemistry
(2015)
7 :1457
-
Evolving function and potential of pancreatic alpha cells
Violeta Stanojevic and Joel F. Habener
Best Practice & Research Clinical Endocrinology & Metabolism
(2015)
29 :859
-
Chemical cholecystokinin receptor activation protects against obesity-diabetes in high fat fed mice and has sustainable beneficial
effects in genetic ob/ob mice
Nigel Irwin, Ian A. Montgomery, R. Charlotte Moffett, and Peter R. Flatt
Biochemical Pharmacology
(2013)
85 :81
-
A synopsis of factors regulating beta cell development and beta cell mass
Krishna Prasadan, Chiyo Shiota, Xiao Xiangwei, David Ricks, Joseph Fusco, and George Gittes
Cellular and Molecular Life Sciences
(2016)
73 :3623
-
GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic -cells from glucolipotoxicity
Z. Liu, V. Stanojevic, L. J. Brindamour, and J. F. Habener
Journal of Endocrinology
(2012)
213 :143
-
Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those
with type 2 diabetes
R. P. Kelly, P. Garhyan, E. Raddad, H. Fu, C. N. Lim, M. J. Prince, J. A. Pinaire, M. T. Loh, and M. A. Deeg
Diabetes, Obesity and Metabolism
(2015)
17 :414
