Skeletal energy homeostasis: a paradigm of endocrine discovery

    1. William P Cawthorn1
    1. 1The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    2. 2The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian, UK
    1. Correspondence should be addressed to K J Suchacki; Email: ksuchack{at}


    Throughout the last decade, significant developments in cellular, molecular and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review focuses on literature from the last decade, addressing the endocrine regulation of global energy metabolism via the skeleton. In addition, we will highlight several recent studies that further our knowledge of new endocrine functions of some organs; explore remaining unanswered questions; and, finally, we will discuss future directions for this more complex era of bone biology research.

    • Received 13 April 2017
    • Accepted 28 April 2017
    • Made available online as an Accepted Preprint 28 April 2017
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