30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Short reflections on the discovery of the mineralocorticoid receptor

    1. Ronald M Evans
    1. Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California, USA
    1. Correspondence should be addressed to R M Evans; Email: evans{at}salk.edu

    Looking back over 30 years, one might assume the fog of time would take its toll, but I still remember the march towards the mineralocorticoid receptor (MR) that began quietly in the summer of 1985 (Fig. 1). We had completed the sequence of the human glucocorticoid receptor (GR), and with the cDNA as probe, found ourselves with a Southern blot which had too many bands for one gene (Fig. 2). I could not get this blot out of my mind, thinking that before my eyes was somehow both a glimpse …

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