Sperm tsRNAs and acquired metabolic disorders

  1. Qiwei Zhai1,2⇑
  1. 1CAS Key Laboratory of Nutrition and Metabolism, CAS Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
  2. 2School of Life Science and Technology, ShanghaiTech University, Shanghai, China
  1. Correspondence should be addressed to Q Zhai; Email: qwzhai{at}sibs.ac.cn
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    Figure 1

    Transmission of acquired metabolic disorders from father to offspring through sperm. Environmental factors such as diet and stress lead to metabolic changes in the germ line of a father that can be transmitted to the offspring. Epigenetic mechanisms including DNA methylation, histone modification, small non-coding RNAs such as tsRNAs, piRNAs and miRNAs, and small RNA modification have been reported. Abbreviations: tsRNAs, tRNA-derived small RNAs; piRNAs, Piwi-interacting RNAs; miRNAs, microRNAs.

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  1. Published online before print June 23, 2016, doi: 10.1530/JOE-16-0185 J Endocrinol 230 F13-F18
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