Figure 1
Current and future therapeutic targets of interventions into folliculogenesis. The figure demonstrates the approximate time span (in days) for the different stages of follicle maturation. Modern infertility treatments of the last 50 years almost exclusively only intervened pharmacologically at the gonadotropin-sensitive last 14 days of follicle maturation. In pointing out future directions for fertility treatments of older women, we here argue that effective therapeutic interventions have to be directed at much earlier stages of follicle maturation, involving small growing follicle stages.
