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  1. ...development of the Edmonton protocol (Shapiro et al. 2006, Pepper et  al. 2013). However, significant obstacles to the widespread implementation of islet transplantation remain unsolved. One of these obstacles is the progressive loss and dysfunction of islets during isolation and transplantation pro ~~~
  2. ...Animal Models to Explore the Effects of Glucocorticoids on Skeletal Growth and 1 Structure 2 3 Claire L Wood1, Ondrej Soucek2,3, Sze C. Wong4, Farasat Zaman3, Colin Farquharson1, Lars 4 Savendahl3, S. Faisal Ahmed4 5 6 1. Division of Developmental Biology, Roslin Institute, University of Edinburgh ~~~
  3. ...2017 Early Developmental Disruption of Type 2 Deiodinase 566 Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid27 577-586. 567 Page 20 of 30 21 Incerpi S, Luly P, De Vito P & Farias RN 1999 Short-term effects of thyroid hormones on the 568 Na/H antiport in L-6 myoblasts: high ~~~
  4. ...development of erythroid lineages were not significantly upregulated 446 (51 genes from An et al. 2014). Recently the expression of haemoglobins in tissues other 447 than erythrocytes has been reported suggesting their role in other basic cellular functions 448 apart from O2 transport [Fordel et al. ~~~
  5. ...development (Richard & Stephens 2011, Lefterova et al. 2014). In pre-adipocytes, PPARγ enhancer regions lead to the recruitment of a transcriptional activation complex, which includes the transcription factors GR, signal transducer and activator of transcription 5A (STAT5A) and retinoid X receptor, ~~~
  6. ...development of obesity in animals with hypothalamic lesions. Physiological Reviews 25 541–559. Coyle EF 1999 Physiological determinants of endurance exercise performance. Journal of Science and Medicine in Sport 2 181–189. (doi:10.1016/S1440-2440(99)80172-8) da Silva RP, Zampieri TT, Pedroso JA, Nag ~~~
  7. ...per litter was counted. A clear association between reduced 202 circulating levels of T4 and a significant reduction in the number of pups with respect to control was 203 observed (CTRL= 12.50 0.97; MMI= 6.4 1.66; Fig.1B). To identify the developmental stage at 204 which hypothyroidism ~~~
  8. ...development of receptor-specific 656 ligands. Semin.Cell Dev.Biol 15 467-476. 657 Proia RL & Hla T 2015 Emerging biology of sphingosine-1-phosphate: its role in pathogenesis 658 and therapy. J Clin.Invest 125 1379-1387. 659 Pyne NJ & Pyne S 2011 Selectivity and specificity of sphingosine 1-phosphate ~~~
  9. ...development of obese pathogenesis such as insulin Figure 6 Influences of MR inhibition on the proinflammatory cytokine expression and ROS production in BMDM. (A) Efficiency of siRNAmediated knockdown of MR in BMDM. (B) Effects of MR-knockdown on proinflammatory cytokine expression in BMDM. Serum-sta ~~~
  10. ...development of HS. We investigated whether providing temporal signals such as 12-h food availability or driving a corticosterone plus melatonin rhythm could restore rhythmicity and prevent the metabolic disturbances under LL conditions in male rats. Discrete metabolic improvements under these separa ~~~
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