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J Mol Endocrinol 2017;58:R15-R31,4l-]4  4 X .  T3z ?D Z $ 2017 The authors*l-]   & X  x 6N  6qљYs ? ̙33ZR___PPT102.]0G+D' = @B D' = @BA?%,( < +O%,( < ++& 5 @b(  @  C ?z7   T3z ? 92   FChemical structures of estrogen receptor agonists and antagonists. (A) The three most abundant circulating estrogens: estrone, 17-estradiol and estriol. (B) Tamoxifen and its active derivatives, 4-hydroxytamoxifen and endoxifen, as well as tamoxifen-derived SERMs. (C) Antiestrogens with different steroid-like backbones and a side chain containing a tertiary amine: SERM raloxifene and related compounds arzoxifene and bazedoxifene, as well as acolbifene. (D) Pure antiestrogens with steroid backbones and long side chains. (E) SERDs with steroid-like backbones and a side chain containing an acrylic acid.*a0 l-]a#  a & X  x 6H  0޽h ? ̙33rP> ^0 ^%Root EntrydO)CompObj9Ole Current User,PicturesSummaryInformation(xPowerPoint Document(]%DocumentSummaryInformation8